Non-invasive control using Sonogenetics

A central challenge in neuroscience is to develop methods to manipulate specific target cells and monitor effects on animal behavior and circuit function. We are developing a new technology using ultrasound as a trigger to control cells expressing specific channels. Ultrasound is non-invasive allowing us to target cells deep within the brain or body without surgical procedures. I will discuss our efforts demonstrating our method in the nematode C. elegans and now in rodents.