Soner Caner Cagun

Brain function depends on the precise coordination of molecular signals across time and space throughout the brain. High-resolution hemodynamic imaging techniques, such as functional magnetic resonance imaging (fMRI) and functional ultrasound imaging (fUSI), provide insights into brain activity by detecting changes in blood oxygenation, flow, and volume through neurovascular coupling. However, these methods offer only indirect measures of brain activity and lack molecular specificity. In contrast, molecular imaging techniques like PET, SPECT, and optical imaging enable direct visualization of biological processes. Yet, PET and SPECT have poor spatiotemporal resolution, while optical imaging is limited by light scattering and shallow tissue penetration.

To overcome these limitations, I am developing novel preclinical molecular imaging approaches based on vasoactive probes and integrating them with fMRI and fUSI.